Course Objectives

After successful completion of this course students will be able to:

1. Explain the physical chemical properties of drugs using drug design software.
2. Draw chemical structures and reactions by Chem draw software.
3. Analyze the purity of medicinal compounds.
4. Prepare medicinally important compounds / intermediates.
5. Synthesize medicinal compounds
6. Estimate partition coefficient of drugs

Learning Outcomes

1. To develop an understanding of the physico-chemical properties of drugs.
2. To understand how current drugs were developed by using pharmacophore modeling and docking technique.
3. To acquire knowledge in the chemotherapy for malaria and microbial diseases and different anti-viral agents.
4. To acquire knowledge about the mechanism pathways of different class of medicinal compounds.
5. To understand the chemistry of antibiotics with respect to their pharmacological activity
6. To know the structural activity relationship of different class of drugs
7. To have been introduced to a variety of drug classes and some pharmacological properties.
8. To acquire knowledge on thrust areas for further research

Course Syllabus

I Preparation of drugs and intermediates

1 Sulphanilamide

2 7-Hydroxy-4-methyl coumarin

3 Chlorobutanol

4 Triphenyl imidazole

5 Tolbutamide

6 Hexamine

II Assay of drugs

1 Isonicotinic acid hydrazide

2 Chloroquine

3 Metronidazole

4 Dapsone

5 Chlorpheniramine maleate

6 Benzyl penicillin

III Preparation of medicinally important compounds or intermediates by Microwave irradiation technique

IV Drawing structures and reactions using chem draw®

V Determination of physicochemical properties such as logP, clogP, MR, Molecular weight, Hydrogen bond donors and acceptors for class of drugs course content using drug design software Drug likeliness screening (Lipinskies RO5)

Session Plan

Session 1

Experiment 1: Preparation of sulfanilamide

https://labmonk.com/synthesis-of-sulphanilamide-from-acetanilide

Session 2

Experiment 2: Preparation of 7-Hydroxy-4-methyl coumarins

https://www.youtube.com/watch?v=prim4KItWRw

Session 3

Experiment 3: Preparation of Chlorobutanol

https://www.youtube.com/watch?v=4VSyEequCII

Session 4

Experiment 4:

Preparation of Triphenyl imidazole

Synthesis of triphenyl imidazole

Session 5

Experiment 5:

Preparation of Tolbutamide

Preparation of Tolbutamide

Session 6

Experiment 6: Preparation of Hexamine

https://www.youtube.com/watch?v=mCCpl08_WjQ

Session 7

Experiment 7:

Assay of Isonicotinic acid hydrazide

Assay of isonicotinic acid hydrazide

Session 8

Experiment 8:

Assay of Chloroquine

Assay of chloroquine

Session 9

Experiment 9:

Assay of Metronidazole

Assay of metronidazole

Session 10

Experiment 10: Assay of Dapsone

https://www.youtube.com/watch?v=MLBsknQihgk

Session 11

Experiment 11: Assay of Chloropheniramine maleate

https://www.youtube.com/watch?v=Zo9hOF9Dd2k

Session 12

Experiment 12:

Assay of Benzyl penicillin

Assay of Benzyl penicillin

Session 13

Experiment 13: Preparation of medicinally important compounds or intermediates by Microwave irradiation technique

https://www.youtube.com/watch?v=wjFc_Tj20oA

https://www.youtube.com/watch?v=iqflFx9BnyU

Session 14

Experiment 14: Drawing structures and reactions using chem draw®

https://www.youtube.com/watch?v=72dX2ikUBdE

https://www.youtube.com/watch?v=037WCSsoivo

Session 15

Experiment 15: Determination of physicochemical properties such as logP, clogP, MR, Molecular weight, Hydrogen bond donors and acceptors for class of drugs course content using drug design software Drug likeliness screening (Lipinskies RO5)

https://www.youtube.com/watch?v=qjABopslM00

https://www.youtube.com/watch?v=vXkAL66Pbes

Case Studies

Case Studies