Course Name : Medicinal Chemistry-I

Code(Credit) : CUTM1572(0-2-0)

Course Objectives

Upon completion of the course the student shall be able to

Understand the chemistry of drugs with respect to their pharmacological activity
Understand the drug metabolic pathways, adverse effect and therapeutic value of drugs
Know the Structural Activity Relationship (SAR) of different class of drugs
Write the chemical synthesis of some drugs

Learning Outcomes

This subject is designed to impart fundamental knowledge on the structure, chemistry and therapeutic value of drugs. The subject emphasizes on structure activity relationships of drugs, importance of physicochemical properties and metabolism of drugs. The syllabus also emphasizes on chemical synthesis of important drugs under each class.

Course Syllabus

I Preparation of drugs/ intermediates
1 1,3-pyrazole
2 1,3-oxazole
3 Benzimidazole
4 Benztriazole
5 2,3- diphenyl quinoxaline
6 Benzocaine
7 Phenytoin
8 Phenothiazine
9 Barbiturate
II Assay of drugs
1 Chlorpromazine
2 Phenobarbitone
3 Atropine
4 Ibuprofen
5 Aspirin
6 Furosemide
III Determination of Partition coefficient for any two drugs