CUTM1647Pharmacology and Pharmaceutical Drug Analysis

CUTM1674 Pharmacology and Pharmaceutical Drug Analysis

CUTM1674 Pharmacology and Pharmaceutical Drug Analysis

Code (Credit): CUTM1647(4-2-0)

Course Objectives

The course aims are to built an understanding about the

• The concept drugs
• Analysis of drug
• Study the drug of abuse
• Study the interaction of drug with body

Learning Objectives:

To know about the drug interaction, analysis of drugs along with drug of abuse

Course syllabus

Unit 1

Basic Principles of Pharmacology:

Introduction to Pharmacology Pharmacopoeias IP, USP, EP Drug & Drug Receptor mechanisms Pharmacodynamics Factor affecting the effects of Drug Post mortem redistribution

Unit II

Pharmacokinetics xL-ADME Bioavailability and Bioaccumulation Dose response relationship Drug Interactions like Agonism, Antagonism, Addition, Synergism, Potentiation Adverse drug reactions and pharmacogenetics Drug concentration and pharmacological response Drug dependence and drug abuse.

Unit III

Pharmacology and Pharmaceutical Analysis

Aliphatic alcohols General and local Anesthetics CNS Stimulants Sedative, Hypnotics and Pharmacotherapy of sleep disorders Drugs effective in convulsive disorders.

Unit IV

Pharmacology and Pharmaceutical Analysis

Antipsychotic Agents Antidepressant drugs Antiseizure Drugs Drugs of Abuse Tranquillizers Narcotic Drugs and Psychotropic Substance Schedule and Nonscheduled Drugs Designer Drugs Doping Drugs Hallucinogens.

Unit V

Pharmacology and Pharmaceutical Analysis

Chemotherapeutic Drugs Antibacterial Antifungal agents Antiviral agents Antiprotozoal Drugs Disinfectants, Antiseptics and Sterilant

Reference Book

• R. J. Flanagan, A. Taylor, I. D. Watson, R. Whelpton, Fundamental of Analytical Toxicology, 2^nd edition (John Wiley & Sons Ltd., 2007), United States
• Toxicological Chemistry, 1^st edi LVIV–2009, Universitatis Medici Leopoliensis Sigillum. AD 1784
• K Vij , Textbook of Forensic Medicine and Toxicology: Principles and Practice, Chapter 30 p. 429,     Basic Consideration in Drugs/Chemicals, 5^th edn., (Elsevier, 2011)
• R.C. Gupta, Veterinary Toxicology Basic and Clinical Principles, Chapter 1, 1^st edi., (Elsevier, 2007), USA

Session 1

Introduction to Pharmacology

https://www.youtube.com/watch?v=r95HUvHa4VM

Session 2

Pharmacopoeias IP, USP, EP

https://qualitymatters.usp.org/what-pharmacopeia

Session 3

Drug & Drug Receptor mechanisms

https://www.msdmanuals.com/en-in/professional/clinical-pharmacology/pharmacodynamics/drug%E2%80%93receptor-interactions#:~:text=Molecules%20(eg%2C%20drugs%2C%20hormones,interact%20with%20multiple%20receptor%20subtypes.

Session 4

Pharmacodynamics

http://samples.jbpub.com/9781449621087/9781449621087_ch06.pdf

Session 5

Factor affecting the effects of Drug

http://www.gmch.gov.in/sites/default/files/documents/FACTORS-AFFECTING-DRUG-ACTION.pdf

Session 6

Post mortem redistribution

https://www.researchgate.net/publication/225298482_Postmortem_Drug_Redistribution

Session 7

L-ADME

https://www.uab.edu/medicine/adda/images/131212%20PK%20ADME.pdf

Session 8

Bioavailability and Bioaccumulation

https://www.epa.gov/sites/default/files/2014-11/documents/bio_final.pdf

Session 9

Dose response relationship

https://www.who.int/foodsafety/chem/dose_response.pdf

Session 10

Drug Interactions like Agonism, Antagonism

https://www2.courses.vcu.edu/ptxed/m2/powerpoint/download/Lamb%20Drug%20Interactions.PDF

Session 11

Addition, Synergism, Potentiation

https://link.springer.com/content/pdf/10.1007%2F978-3-7091-9276-4_3.pdf

Session 12

Adverse drug reactions and pharmacogenetic

https://www.researchgate.net/publication/280444609_Pharmacogenetics_of_Adverse_Drug_Reactions

Session 13

Drug dependence and drug abuse

https://apps.who.int/iris/bitstream/handle/10665/267205/PMC2555251.pdf?sequence=1&isAllowed=y

Session 14

Aliphatic alcohols

https://www.ncbi.nlm.nih.gov/books/NBK557381/

Session 15

General and local Anesthetics

https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/338535/Chloroform_Toxicological_Overview.pdf

Session 16

CNS Stimulants

https://apps.sdsheriff.net/PublicDocs/SB978/Detention%20Services%20Bureau/Detention%20Academy/DCSA%20Dept%20Supp/Narcotics%20Orientation/CNS%20Stimulants%20(2016-06).pdf

Session 17

Sedative, Hypnotics and Pharmacotherapy of sleep disorders

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC181172/

Session 18

Drugs effective in convulsive disorders

Session 19

Antipsychotic Agent

Session 20

Antidepressant drugs

Session 21

Antiseizure Drugs

Session 22

Drugs of Abuse

Session 23

Tranquillizers

Session 24

Narcotic Drugs and Psychotropic Substance

Session 25

Schedule and Nonscheduled Drugs

Session 26

Designer Drugs

Session 27

Doping Drugs

Session 28

Hallucinogen

Session 29

Chemotherapeutic Drugs

Session 30

Antibacterial

Session 31

Antifungal agents

Session 32

Antiprotozoal Drugs

Session 33

Disinfectants, Antiseptics

Session 34

Sterilants